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September 2, 2025Open Access

Figure S20 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Sanya Mehta Siri Ippagunta Srinidhi Varadharajan Alisha Kardian Nic Laboe Diana Dinh Amber B. Jones Michaela Meehl Jorge Ibañez-Vega Erik Emanus Tram Dao Meghan B. Ward Wilda Orisme Shannon Lange Deanna Langfitt Jeffrey Steinberg Jason Chiang Peter Vogel Heather Sheppard David W. Ellison Stephen C. Mack Giedre Krenciute

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Key Points

Murine B7-H3 CAR T cells effectively reduce tumor cells in vitro, demonstrating significant potential against ependymomas.
Evidence shows murine B7-H3 CAR T cells have efficacy against murine ZFTA-RELA EPN, indicating a promising treatment path.
In vitro assessment of B7-H3 CAR T cells against ependymomas highlights limitations due to tumor size and immune response.
Findings underscore the need for strategies to enhance CAR T cell effectiveness against larger tumors and immune barriers.

Implication

In vitro analysis demonstrates effectiveness of B7-H3 CAR T cells against ZFTA-RELA EPN cells, suggesting potential for targeted therapy.

Abstract

Figure S20 shows in vitro efficacy of murine B7-H3.CAR T-cells against murine ZFTA-RELA EPN cell line.

Discussion

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Cite This Study

Mehta et al. (2025) studied this question.

synapsesocial.com/papers/68bb4e016d6d5674bcd029c5 https://doi.org/10.1158/1078-0432.30028517

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S16 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response2025
2Figure S22 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response2025
3Figure S21 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response2025
4Figure S2 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response2025
5Figure S3 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response2025

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