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September 2, 2025Open Access

Figure S3 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Sanya Mehta Siri Ippagunta Srinidhi Varadharajan Alisha Kardian Nic Laboe Diana Dinh Amber B. Jones Michaela Meehl Jorge Ibañez-Vega Erik Emanus Tram Dao Meghan B. Ward Wilda Orisme Shannon Lange Deanna Langfitt Jeffrey Steinberg Jason Chiang Peter Vogel Heather Sheppard David W. Ellison Stephen C. Mack Giedre Krenciute

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Key Points

B7-H3 CAR T cells effectively target ependymomas, but their efficacy diminishes with larger tumor size.
Regulation of B7-H3 transcriptional activity by ZFTA-RELA oncogene demonstrates the complexity of immune responses.
Analysis of relationship between tumor size and immune response using B7-H3 CAR T cells reveals significant challenges.
Findings indicate potential for targeted therapy, but limits imposed by immune response and tumor size need addressing.

Implication

Observational analysis reveals B7-H3 CAR T cells target ependymomas, suggesting limitations from tumor size and immune response.

Abstract

Figure S3 shows regulation of B7-H3 transcriptional activity by ZFTA-RELA oncogene.

Discussion

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Cite This Study

Mehta et al. (2025) studied this question.

synapsesocial.com/papers/68bb4e016d6d5674bcd029a9 https://doi.org/10.1158/1078-0432.30028505

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S2 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response2025
2Figure S20 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response2025
3Figure S22 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response2025
4Figure S16 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response2025
5Figure S21 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response2025

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