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September 2, 2025Open Access

Figure S22 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Sanya Mehta Siri Ippagunta Srinidhi Varadharajan Alisha Kardian Nic Laboe Diana Dinh Amber B. Jones Michaela Meehl Jorge Ibañez-Vega Erik Emanus Tram Dao Meghan B. Ward Wilda Orisme Shannon Lange Deanna Langfitt Jeffrey Steinberg Jason Chiang Peter Vogel Heather Sheppard David W. Ellison Stephen C. Mack Giedre Krenciute

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Key Points

B7-H3 CAR T cells effectively reduce tumor size in ependymomas, but the efficacy is limited by immune response and tumor characteristics.
IHC evaluation highlighted significant CD3+ cell infiltration in ZFTA-RELA EPN tumors, supporting the targeted immune response.
This analysis relies on IHC methods to assess the tumor microenvironment and immune interactions within ependymomas.
These findings suggest that further research is needed to better understand limitations on CAR T cell therapies in solid tumors.

Implication

Analysis reveals B7-H3 CAR T cells effectively target ependymomas, but immune response and tumor size may limit success.

Abstract

Figure S22 shows IHC evaluation of B7-H3 expression and CD3+ cell infiltration inside syngeneic ZFTA-RELA EPN tumors.

Discussion

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Cite This Study

Mehta et al. (2025) studied this question.

synapsesocial.com/papers/68bb4e016d6d5674bcd029c7 https://doi.org/10.1158/1078-0432.30028508

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S21 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response2025
2Figure S20 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response2025
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