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September 2, 2025Open Access

Figure S1 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Sanya Mehta Siri Ippagunta Srinidhi Varadharajan Alisha Kardian Nic Laboe Diana Dinh Amber B. Jones Michaela Meehl Jorge Ibañez-Vega Erik Emanus Tram Dao Meghan B. Ward Wilda Orisme Shannon Lange Deanna Langfitt Jeffrey Steinberg Jason Chiang Peter Vogel Heather Sheppard David W. Ellison Stephen C. Mack Giedre Krenciute

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Key Points

B7-H3 CAR T cells demonstrate significant effectiveness against ependymomas.
Tumor size was identified as a limiting factor in the efficacy of B7-H3 CAR T cells.
Immune response also significantly impacts the effectiveness of B7-H3 CAR T cell therapy.
The findings highlight the need for strategies to enhance CAR T cell effectiveness in larger tumors.

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Implication

Analysis reveals B7-H3 CAR T cells effectively target ependymomas, but tumor size and immune response may limit effectiveness.

Abstract

Figure S1 shows representative B7-H3 staining intensity scale.

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Cite This Study

Mehta et al. (2025) studied this question.

synapsesocial.com/papers/68bb4e016d6d5674bcd02970 https://doi.org/10.1158/1078-0432.30028556

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S5 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response2025
2Figure S7 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response2025
3Figure S15 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response2025
4Figure S6 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response2025
5Figure S14 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response2025

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Figure S11 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response2025
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Table S1 and S2 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response2025