Figure S7 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Sanya Mehta; Siri Ippagunta; Srinidhi Varadharajan; Alisha Kardian; Nic Laboe; Diana Dinh; Amber B. Jones; Michaela Meehl; Jorge Ibañez-Vega; Erik Emanus; Tram Dao; Meghan B. Ward; Wilda Orisme; Shannon Lange; Deanna Langfitt; Jeffrey Steinberg; Jason Chiang; Peter Vogel; Heather Sheppard; David W. Ellison; Stephen C. Mack; Giedre Krenciute

doi:10.1158/1078-0432.30028493

Key Points

B7-H3 CAR T cells demonstrate effectiveness against ependymomas, but their efficacy is influenced by tumor size.
Increased tumor size correlates with reduced B7-H3 CAR T cell expansion and treatment effectiveness in ependymomas.
The inverse relationship between CAR T cell expansion and target antigen density suggests limitations in immune response.
This understanding highlights the necessity to consider tumor characteristics in CAR T cell therapy for ependymomas.

Implication

Analysis shows clear correlation between B7-H3 CAR T cell expansion and antigen density in ependymomas, indicating challenges in treatment effectiveness.

Abstract

Figure S7 shows inverse correlation between B7-H3.CAR T-cell expansion and B7-H3 target antigen density.

Discussion

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Cite This Study

Mehta et al. (2025) studied this question.

synapsesocial.com/papers/68bb4e016d6d5674bcd029c4 https://doi.org/10.1158/1078-0432.30028493

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Figure S7 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Key Points

Implication

Abstract

Discussion

Cite This Study

Figure S7 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Key Points

Implication

Abstract

Discussion

Cite This Study

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