Figure S6 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Key Points

B7-H3 CAR T-cells may be effective against ependymomas, but their efficacy is influenced by tumor size.
Expansion of B7-H3 CAR T-cells relates closely to antigen density found on ependymoma cells.
Immune response mechanisms also play a critical role in determining the effectiveness of the CAR T-cell therapy.
Further understanding of the relationship between tumor size and immune response is necessary for better outcomes.

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Observational analysis revealed B7-H3 CAR T-cell expansion depends on antigen density in ependymomas, implying immune response constraints.

Figure S6 shows B7-H3.CAR T-cell expansion vs EPN cell target antigen density.

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Mehta et al. (2025) studied this question.

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