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September 2, 2025Open Access

Figure S17 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Sanya Mehta Siri Ippagunta Srinidhi Varadharajan Alisha Kardian Nic Laboe Diana Dinh Amber B. Jones Michaela Meehl Jorge Ibañez-Vega Erik Emanus Tram Dao Meghan B. Ward Wilda Orisme Shannon Lange Deanna Langfitt Jeffrey Steinberg Jason Chiang Peter Vogel Heather Sheppard David W. Ellison Stephen C. Mack Giedre Krenciute

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Key Points

B7-H3 CAR T cells effectively controlled ependymomas in vivo, indicating therapeutic potential.
In studies, PFA EPN xenografts showed effective control with B7-H3 CAR T cells, highlighting a promising treatment route.
Strategies must address limitations in tumor size and immune response to maximize CAR T cell effectiveness.
The findings emphasize the need for further investigation into optimizing CAR T cell therapies for ependymomas.

Implication

In vivo analysis found B7-H3 CAR T cells effectively control ependymomas, suggesting tumor size and immune response may limit treatment efficacy.

Abstract

Figure S17 shows effective control of PFA EPN xenografts by B7-H3.CAR T-cells in vivo.

Discussion

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Cite This Study

Mehta et al. (2025) studied this question.

synapsesocial.com/papers/68bb4e016d6d5674bcd0295d https://doi.org/10.1158/1078-0432.30028529

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S16 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response2025
2Figure S12 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response2025
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4Figure S19 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response2025
5Figure S20 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response2025

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