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September 2, 2025Open Access

Figure S5 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Sanya Mehta Siri Ippagunta Srinidhi Varadharajan Alisha Kardian Nic Laboe Diana Dinh Amber B. Jones Michaela Meehl Jorge Ibañez-Vega Erik Emanus Tram Dao Meghan B. Ward Wilda Orisme Shannon Lange Deanna Langfitt Jeffrey Steinberg Jason Chiang Peter Vogel Heather Sheppard David W. Ellison Stephen C. Mack Giedre Krenciute

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Key Points

B7-H3 CAR T cells showed effectiveness against ependymomas, but their impact is limited by tumor size.
Impact on immune response was observed, suggesting important interactions that affect treatment outcomes.
Analysis of phenotypic characteristics indicates crucial features of human B7-H3 CAR T cells.
Findings emphasize the need for understanding tumor microenvironment interactions for deeper insights.

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Implication

This analysis demonstrates B7-H3 CAR T cell effectiveness against ependymomas, highlighting size and immune response limitations.

Abstract

Figure S5 shows phenotypic characteristics of human B7-H3.CAR T-cells.

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Cite This Study

Mehta et al. (2025) studied this question.

synapsesocial.com/papers/68bb4e016d6d5674bcd029f3 https://doi.org/10.1158/1078-0432.30028499

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1Figure S11 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response2025
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