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September 2, 2025Open Access

Figure S9 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Sanya Mehta Siri Ippagunta Srinidhi Varadharajan Alisha Kardian Nic Laboe Diana Dinh Amber B. Jones Michaela Meehl Jorge Ibañez-Vega Erik Emanus Tram Dao Meghan B. Ward Wilda Orisme Shannon Lange Deanna Langfitt Jeffrey Steinberg Jason Chiang Peter Vogel Heather Sheppard David W. Ellison Stephen C. Mack Giedre Krenciute

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Key Points

B7-H3 CAR T-cells demonstrate effectiveness against ependymomas, yet their impact is limited by tumor size and immune response.
Type 2 polarization of B7-H3 CAR T-cells occurs after repetitive stimulation with ependymoma cells, suggesting adaptive responses.
Analysis of CAR T-cells targeting B7-H3 shows notable results, but challenges from tumor size and immune interactions remain.
Implications from the study highlight the need for further research on enhancing CAR T-cell efficacy against solid tumors.

Implication

Observational analysis reveals B7-H3 CAR T-cells' effectiveness against ependymomas, indicating limitations from tumor size and immune response.

Abstract

Figure S9 shows Type 2 polarization of B7-H3.CAR T-cells over repetitive stimulation with EPN cells.

Discussion

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Cite This Study

Mehta et al. (2025) studied this question.

synapsesocial.com/papers/68bb4e016d6d5674bcd02956 https://doi.org/10.1158/1078-0432.30028484

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S6 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response2025
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