Figure S13 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Key Points

Cytokine secretion from HER2.CAR T cells increased following repeated stimulation with EPN cells, showing promise.
Increased levels of cytokines indicate that CAR T cells can be effective in targeting ependymomas despite limitations.
Assessment revealed that tumor size and immune response may significantly influence the effectiveness of CAR T cell therapy.
Findings suggest further investigation into overcoming identified challenges in CAR T cell treatment for ependymomas.

Observational analysis reveals enhanced cytokine secretion from CAR T cells in ependymoma, highlighting tumor size and immune response constraints.

Figure S13 shows sustained or increased cytokine secretion of HER2.CAR T-cells following repetitive stimulation with EPN cells.

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Mehta et al. (2025) studied this question.

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