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September 2, 2025Open Access

Table S1 and S2 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Sanya Mehta Siri Ippagunta Srinidhi Varadharajan Alisha Kardian Nic Laboe Diana Dinh Amber B. Jones Michaela Meehl Jorge Ibañez-Vega Erik Emanus Tram Dao Meghan B. Ward Wilda Orisme Shannon Lange Deanna Langfitt Jeffrey Steinberg Jason Chiang Peter Vogel Heather Sheppard David W. Ellison Stephen C. Mack Giedre Krenciute

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Key Points

B7-H3 CAR T cells effectively target ependymomas, showing potential in tumor treatment.
The effectiveness of the CAR T cells is hindered by the size of the tumor and immune response factors.
The observational analysis reveals significant findings regarding tumor size and immune factors in ependymoma treatment.
Limitations identified call for further research on optimizing CAR T cell efficacy against varying tumor conditions.

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Implication

B7-H3 CAR T cells demonstrate effectiveness against ependymomas, suggesting tumor size and immune response may limit treatment outcomes.

Abstract

Supplementary Tables S1 and S2

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Cite This Study

Mehta et al. (2025) studied this question.

synapsesocial.com/papers/68bb4e016d6d5674bcd028db https://doi.org/10.1158/1078-0432.30028481

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1Figure S5 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response2025
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