Introduction . Bladder cancer is one of the most prevalent malignancies, characterized by high rates of recurrence and progression—even in its superficial forms, such as non-muscle-invasive bladder cancer (NMIBC). Recent research has increasingly focused on the molecular and genetic profiles of these tumors, as these factors, together with tumor grade and stage, play a crucial role in determining disease prognosis. Objective . To investigate the impact of molecular genetic subtypes in NMIBC on disease prognosis and assess the feasibility of their evaluation in routine clinical practice. Materials 59.3%), luminal-like (51; 31.5%), intermediate (5; 3.1%), and basal-squamous-like (10; 6.2%). During follow-up, recurrence and progression rates differed significantly between groups. Luminal tumors exhibited low recurrence (33.3%) and progression rates (2.1%), while luminal-like tumors showed higher recurrence (54.9%) but maintained low progression risk (5.9%). In contrast, intermediate and basal-squamous-like subtypes were associated with aggressive behavior: both demonstrated high recurrence rates (100% and 90.0%, respectively) and elevated progression risk (25.0% and 50.0%, respectively) (p < 0.05). Conclusion . Basal-squamous-like tumors demonstrate the worst prognosis in terms of disease recurrence and progression, necessitating more aggressive treatment, whereas luminal tumors are associated with the most favorable outcomes.
Sargsian et al. (Wed,) studied this question.