What type of study is this?

This is a Experimental Study study.

September 17, 2025

Multiparametric MRI evaluation of early renal fibrosis and therapeutic effect of asiatic acid in an experimental rat model

Puntos clave

Multiparametric MRI can effectively evaluate the degree of renal fibrosis in experimental models.
Results indicate that the treatment with asiatic acid has measurable therapeutic effects on renal injury models.
Methodologies included MRI and immunohistochemical examinations to assess kidney structure and function.
This technique highlights the potential for early detection of microstructural changes in chronic kidney disease.

Resumen

Motivation: Noninvasive MRI techniques such as ASL, DKI and T1 imaging have not been adequately validated in detecting kidney injury and renal fibrosis. Goal(s): To prove that multiparameter MRI can evaluate the degree of renal fibrosis and the therapeutic effect of treatment. Approach: MRI, immunohistochemical, and pathological examinations were performed for the renal injury model group and the treatment group. Results: Multiparameter MRI can dynamically evaluate renal fibrosis and therapeutic efficacy of treatment. The method can detect changes in renal structure, function, internal molecular metabolism, and post-treatment efficacy in rats with renal fibrosis. Impact: Multiparametric MRI has the potential to noninvasively detect early microstructural changes in patients with CKD before a significant renal functional decline and can determine proof of activity for evaluating therapies.

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