Evaluating intra-voxel incoherent motion in the uterine cervix: healthy volunteer repeatability and therapy-induced changes in tumours

There is a need for robust imaging biomarkers which can be used to assess early tumour response to therapy. Intra-voxel incoherent motion (IVIM) can provide information about tumour microstructure and microvasculature, but requires technical and biological validation. This work evaluates IVIM repeatability in the uterine cervix of healthy volunteers, assesses the sensitivity of IVIM parameters to therapy in patients with uterine cervical cancer, and evaluates model suitability through a model comparison framework.