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There is a need for robust imaging biomarkers which can be used to assess early tumour response to therapy. Intra-voxel incoherent motion (IVIM) can provide information about tumour microstructure and microvasculature, but requires technical and biological validation. This work evaluates IVIM repeatability in the uterine cervix of healthy volunteers, assesses the sensitivity of IVIM parameters to therapy in patients with uterine cervical cancer, and evaluates model suitability through a model comparison framework.
Datta et al. (Wed,) studied this question.