Nine-Fold Acceleration of Multi-Parametric Imaging of the Brain through Joint Sparsity regularized Wave-SPIRiT reconstruction

The MULTIPLEX technique could quantify the T1/T2*/PD/Susceptibility maps in a single 3D scan but leads to a long scan time due to the dual-TR, dual-flip angle, and multi-echo signal acquisition strategy. Wave-CAIPI acceleration with SENSE reconstruction is limited by noise amplification at high acceleration factors and is susceptible to artifacts from inaccurate coil sensitivity maps. This work develops a L1 regularized Wave-SPIRiT reconstruction to achieve 9-fold accelerated MULTIPLEX imaging in 3 minutes. The L1 regularized coil-by-coil reconstruction also benefits the Multi-Dimensional Integration (MDI) quantification to achieve comparable accuracy and robustness as the reference scan with 55% reduction of scan time.