February 25, 2024Open Access

Jianpi Jiedu decoction reverses 5-fluorouracil resistance in colorectal cancer by suppressing the xCT/GSH/GPX4 axis to induce ferroptosis

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Resumen

Innate and acquired chemoresistance in colorectal cancer (CRC) often results in 5-fluorouracil (5-FU) treatment failure. This study aimed to investigate the potential of Jianpi Jiedu (JPJD) decoction to reverse 5-FU resistance in CRC and clarify its potential mechanism of action.

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Cite This Study

Ou et al. (Sun,) studied this question.

synapsesocial.com/papers/68e779f3b6db6435876eef71 https://doi.org/https://doi.org/10.1016/j.heliyon.2024.e27082

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1Jianpi Jiedu Recipe inhibits colorectal cancer liver metastasis via regulating ITGBL1-rich extracellular vesicles mediated activation of cancer-associated fibroblasts2022 · 34 citations
2Chinese medicine for outcomes in colorectal cancer patients: A retrospective clinical study2016 · 19 citations
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4Inhibit or Evade Multidrug Resistance P-Glycoprotein in Cancer Treatment2017 · 393 citations
5Use of Jianpi Jiedu Herbs in Patients with Advanced Colorectal Cancer: A Systematic Review and Meta‐Analysis2018 · 24 citations

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