Experimental analysis demonstrates reversal of 5-fluorouracil resistance by Jianpi Jiedu decoction in colorectal cancer, suggesting a ferroptosis-mediated mechanism.
Innate and acquired chemoresistance in colorectal cancer (CRC) often results in 5-fluorouracil (5-FU) treatment failure. This study aimed to investigate the potential of Jianpi Jiedu (JPJD) decoction to reverse 5-FU resistance in CRC and clarify its potential mechanism of action.
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Ou et al. (2024) studied this question.
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