What question did this study set out to answer?

This research aims to investigate the relationship between the C-reactive protein/HDL cholesterol ratio and stroke risk in adults with varying glycemic status.

February 13, 2026Open Access

Association of C-reactive protein/high-density lipoprotein cholesterol ratio with stroke in Chinese adults across different glycemic status

Puntos clave

This research aims to investigate the relationship between the C-reactive protein/HDL cholesterol ratio and stroke risk in adults with varying glycemic status.
Analyzed the association between C-reactive protein/HDL cholesterol ratio and stroke incidence.
Considered different glycemic statuses: normal glucose regulation (NGR) and diabetes.
Utilized statistical analyses to assess risk and discriminative ability.
Higher C-reactive protein/HDL cholesterol ratio is linked to an increased stroke risk.
The association is stronger and nonlinear in individuals with normal glucose regulation compared to those with diabetes.
C-reactive protein/HDL cholesterol ratio has limited ability to predict stroke on its own.

Resumen

Higher CHR was associated with an increased risk of stroke in Chinese adults, with heterogeneity across glycemic status, showing stronger and nonlinear (J-shaped) associations in NGR than in diabetes. CHR demonstrated limited discriminative ability for stroke, suggesting its utility may lie in risk stratification rather than standalone prediction.

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