Coronavirus disease COVID-19 is an infectious viral disease that has rapidly spread throughout the world and developed into a global pandemic in 2020. The clinical spectrum of COVID-19 is diverse and range from asymptomatic infection to respiratory failure and death. The etiology of COVID-19 clinical course is not well understood. The role of many factors is assumed, including the genetic characteristics of the individual. Replicative association analysis COVID-19 severity with the single nucleotide variant (SNV) rs73064425 of the gene was performed. According to GWAS this SNV is associated with COVID-19 severe form. The polymorphism rs73064425 was showed a significant association with COVID-19 severe form in the Russian population of Tomsk. Possible mechanisms of the studied SNV involvement in the disease pathogenesis are discussed. Frequencies variability of the risk allele T rs73064425 was found in populations of the world.
R.A. Korneeva (Wed,) studied this question.