What question did this study set out to answer?

To investigate the association between the gene polymorphism rs73064425 and the severity of COVID-19.

February 25, 2026

Association of the Gene Polymorphic Marker rs73064425 with Severity of COVID-19 and Its Allele Frequencies World-Wide Distribution

Key Points

To investigate the association between the gene polymorphism rs73064425 and the severity of COVID-19.
Conducted replicative association analysis for COVID-19 severity with SNV rs73064425.
Utilized data from the Russian population in Tomsk for analysis.
Discussed possible involvement mechanisms of the SNV in the disease pathogenesis.
Significant association found between rs73064425 and severe COVID-19 in the Tomsk population.
Frequencies of the risk allele T vary across global populations.

Abstract

Coronavirus disease COVID-19 is an infectious viral disease that has rapidly spread throughout the world and developed into a global pandemic in 2020. The clinical spectrum of COVID-19 is diverse and range from asymptomatic infection to respiratory failure and death. The etiology of COVID-19 clinical course is not well understood. The role of many factors is assumed, including the genetic characteristics of the individual. Replicative association analysis COVID-19 severity with the single nucleotide variant (SNV) rs73064425 of the gene was performed. According to GWAS this SNV is associated with COVID-19 severe form. The polymorphism rs73064425 was showed a significant association with COVID-19 severe form in the Russian population of Tomsk. Possible mechanisms of the studied SNV involvement in the disease pathogenesis are discussed. Frequencies variability of the risk allele T rs73064425 was found in populations of the world.

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Cite This Study

R.A. Korneeva (Wed,) studied this question.

synapsesocial.com/papers/699e9166f5123be5ed04eeff https://doi.org/https://doi.org/10.7868/s3034510325090092

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