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This research develops a genotyping method for identifying genetic markers linked to COVID-19 severity in a Russian population, suggesting new tools for understanding infection progression.
COVID-19 is a severe acute respiratory infection caused by the SARS-CoV-2 virus. Research in the field of host genetics contributes to the discovery of new genomic markers of coronavirus infection progression. In this article, a method for multiplex genotyping of polymorphic variants of genes associated with the severity of COVID-19 has been developed, based on multilocus PCR and MALDI-TOF mass spectrometry of DNA molecules. The frequencies of 45 single nucleotide polymorphisms of COVID-19 candidate genes in a population sample of Russians from Tomsk are characterized. The results are compared with data for populations from the 1000 Genomes Project.
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A.V. Bocharova (2025) studied this question.
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