An enantioselective formal 5+2 annulation strategy for the efficient synthesis of seven-membered bridged biaryls is reported through palladium-catalyzed asymmetric annulative allylic alkylation of o-indolizinyl N-sulfonylanilines with (Z)-butene dicarbonate. This reaction features mild conditions, excellent enantioselectivity, and a broad substrate scope. The potential scalability and late-stage elaboration demonstrate the practicality of this protocol.
Li et al. (Thu,) studied this question.