Formal annulation strategy achieves efficient synthesis of bridged biaryls, suggesting practical applications for complex molecules.
An enantioselective formal [5+2] annulation strategy for the efficient synthesis of seven-membered bridged biaryls is reported through palladium-catalyzed asymmetric annulative allylic alkylation of o-indolizinyl N-sulfonylanilines with (Z)-butene dicarbonate. This reaction features mild conditions, excellent enantioselectivity, and a broad substrate scope. The potential scalability and late-stage elaboration demonstrate the practicality of this protocol.
No takes yet. Share an insight, caveat, or question.
Li et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: