Phosphine‐Catalyzed Enantioselective [2 + 2] Annulations of α ‐Allyl γ ‐Benzyl Allenoates via a Transannular Cyclization Approach

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Bicyclo[3.2.0]heptenes achieved high yields and excellent enantioselectivity.
Yielding 94% enantiomeric excess in dynamic kinetic resolution, involving zwitterion formation.
The protocol utilized phosphine-catalyzed annulations to resolve ring strain in cyclobutane synthesis.
This method may enable new avenues for pharmaceuticals and drug discovery through efficient synthesis.

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Catalyzed enantioselective cyclobutane formation shows dynamic kinetic resolution, suggesting methods for pharmaceutical synthesis.

Xiao et al. (2025) studied this question.

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