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March 2, 2026Open Access

The Benefits of Exercise-induced Cereblon on Cardiac and Skeletal Muscle

Puntos clave

This research aims to explore how exercise affects cereblon regulation in cardiac and skeletal muscle.
Analyzed the role of cereblon in the E3 ubiquitin ligase complex.
Examined the relationship between exercise and AMPK activity.
Investigated cellular mechanisms of cereblon during exercise training.
Cereblon significantly influences AMPK activity during exercise.
Exercise induces alterations in cereblon levels in both cardiac and skeletal muscle.
Improved muscle function linked to enhanced cereblon regulation.

Resumen

Background Cereblon (CRBN) serves as a substrate receptor of the E3 ubiquitin ligase complex and plays a critical role in regulating AMPK activity. Exercise is known to be a key modulator of AMPK. However, the precise cellular mechanisms governing CRBN regulation during exercise training remain unclear.

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The Benefits of Exercise-induced Cereblon on Cardiac and Skeletal Muscle | Synapse

Cite This Study

Seo et al. (Thu,) studied this question.

synapsesocial.com/papers/69a528ecf1e85e5c73bf0638 https://doi.org/https://doi.org/10.14789/ejmj.jmj26-0032-s