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Exercise demonstrates benefits on cardiac and skeletal muscle through CRBN regulation, indicating potential health improvements.
Background Cereblon (CRBN) serves as a substrate receptor of the E3 ubiquitin ligase complex and plays a critical role in regulating AMPK activity. Exercise is known to be a key modulator of AMPK. However, the precise cellular mechanisms governing CRBN regulation during exercise training remain unclear.
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Seo et al. (2026) studied this question.
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