What does this research mean for the field?

Restoration of CREB function drives adaptive, physiological cardiac hypertrophy by enhancing the expression of genes that promote mitochondrial oxidative capacity and resistance to apoptosis, whereas CREB function remains depressed in pathological hypertrophy. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 3, 2007AJP Heart and Circulatory Physiology

Restoration of CREB function is linked to completion and stabilization of adaptive cardiac hypertrophy in response to exercise

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Why the study?

Does exercise training improve cardiac phenotype and mitochondrial function via CREB activation in animal models of left ventricular hypertrophy?

Population

Female Sprague-Dawley rats and female C57Bl/6 mice, spontaneously hypertension heart failure rats and…

Comparison

Exercise training and adenovirus-mediated… vs Sedentary controls

Design

Preclinical

Authors

PWP.A. WatsonUniversity of Bristol JRJane E.B. ReuschGeneral / Preventive / Lipids SMSylvia A. McCuneUniversity of Colorado Boulder

Discussion

Member takes

Implication

Hypothesis-generating for CREB-mediated benefits in rodent LV failure; leaves open translation to human HF exercise therapy.

Structured PICO

Does exercise training improve cardiac phenotype and mitochondrial function via CREB activation in animal models of left ventricular hypertrophy?

Population

Female Sprague-Dawley rats and female C57Bl/6 mice (physiological LV hypertrophy models), spontaneously hypertension heart failure (SHHF) rats and hypertrophic cardiomyopathy (HCM) transgenic mice (pathological LV hypertrophy models), and neonatal rat cardiac cells

Intervention

Exercise training (involuntary treadmill running or voluntary wheel running) and adenovirus-mediated expression of constitutively active CREB

Comparator

Sedentary controls

Outcome

CREB serine-133 phosphorylation, bcl-2 expression, caspase 9 and 3 activation, PGC-1 expression, and LV mitochondrial respiratory rates and protein contentsurrogate

Restoration of CREB function through exercise contributes to adaptive cardiac hypertrophy by enhancing oxidative capacity and resistance to apoptosis in both physiological and pathological models.

Cite This Study

Watson et al. (2007) studied this question.

synapsesocial.com/papers/6a1bf04000ee29383e9d2e2c https://doi.org/10.1152/ajpheart.00734.2006

Topics

Hypertension management

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Restoration of CREB function is linked to completion and stabilization of adaptive cardiac hypertrophy in response to exercise

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Restoration of CREB function is linked to completion and stabilization of adaptive cardiac hypertrophy in response to exercise

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Topics

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