Adjunctive use of Saccharomyces boulardii versus bismuth subsalicylate in the management of non-Clostridioides difficile nosocomial diarrhea in severely ill patients: a three-arm randomized controlled trial

Puntos clave

• Saccharomyces boulardii may improve management of nosocomial diarrhea compared to bismuth subsalicylate, and highlights a potential treatment avenue for severely ill patients.
• The trial reveals significant differences in diarrhea management between the two adjunctive treatments, likely influencing future clinical practices.
• Conducted as a randomized controlled trial, this study offers robust data on treatment efficacy and safety in a critical care setting.
• The findings support further exploration of adjunctive therapies for digestive issues in severely ill individuals, warranting larger-scale studies.