Adjunctive use of Saccharomyces boulardii versus bismuth subsalicylate in the management of non-Clostridioides difficile nosocomial diarrhea in severely ill patients: a three-arm randomized controlled trial

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Key Points

Saccharomyces boulardii may improve management of nosocomial diarrhea compared to bismuth subsalicylate, and highlights a potential treatment avenue for severely ill patients.
The trial reveals significant differences in diarrhea management between the two adjunctive treatments, likely influencing future clinical practices.
Conducted as a randomized controlled trial, this study offers robust data on treatment efficacy and safety in a critical care setting.
The findings support further exploration of adjunctive therapies for digestive issues in severely ill individuals, warranting larger-scale studies.

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Randomized controlled trial compares effectiveness of fungi and bismuth for diarrhea in severely ill patients, suggesting a new treatment option.

Thai Clinical Trials Registry Identifier TCTR20250904004.

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Preechakawin et al. (2026) studied this question.

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