Observational analysis evaluates prognostic markers for severe liver disease in children, highlighting reliability issues.
Neither the SCOPE index at diagnosis nor GGT normalization within 1 year predicted severe liver disease course. No clinical factors (sex, age at diagnosis, presence of IBD, features of AIH, or PSC subtype) or laboratory markers were found to reliably predict a severe disease course. Overall, the long-term prognosis in this pediatric cohort was generally favorable.
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Vlckova et al. (2026) studied this question.
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