Impact of low-dose sufentanil on the effective sedative dose of ciprofol for BIS-guided induction in elderly patients: an up-and-down sequential allocation trial | Synapse
March 3, 2026Open Access
Impact of low-dose sufentanil on the effective sedative dose of ciprofol for BIS-guided induction in elderly patients: an up-and-down sequential allocation trial
Puntos clave
Effective sedative doses of ciprofol may decrease when combined with low-dose sufentanil, enhancing sedation safety.
In a sample of elderly patients, the study used an up-and-down sequential allocation trial design to assess induction impacts.
With a focus on sedation levels guided by the Bispectral Index (BIS), the design allowed precise dose adjustments throughout the trial.
These findings imply improved sedation strategies, especially for high-risk elderly patients undergoing procedures.