Impact of low-dose sufentanil on the effective sedative dose of ciprofol for BIS-guided induction in elderly patients: an up-and-down sequential allocation trial

January 29, 2026Frontiers in MedicineOpen Access

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Key Points

Effective sedative doses of ciprofol may decrease when combined with low-dose sufentanil, enhancing sedation safety.
In a sample of elderly patients, the study used an up-and-down sequential allocation trial design to assess induction impacts.
With a focus on sedation levels guided by the Bispectral Index (BIS), the design allowed precise dose adjustments throughout the trial.
These findings imply improved sedation strategies, especially for high-risk elderly patients undergoing procedures.

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Up-and-down sequential allocation trial examines sedative dose interaction in elderly patients, suggesting improved safety profiles.

http://www.chictr.org.cn, identifier: ChiCTR2400090926.

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Qing et al. (2026) studied this question.

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