Insight into the Retention Behaviours of Proton Pump Inhibitor Drugs Using Homemade ZIC-HILIC Columns with Greenness, Whiteness, and Blueness Evaluation

Puntos clave

• Retention behaviour of proton pump inhibitors is influenced by specific homemade ZIC-HILIC columns, emphasizing the importance of design.
• The evaluation of greenness, whiteness, and blueness metrics shows significant differences in retention patterns and properties of these drugs.
• The method employed synthesizes custom ZIC-HILIC columns that enhance the understanding of how proton pump inhibitors are retained during analysis.
• Further validation of these metrics in various settings may enhance analytical applications of proton pump inhibitors, indicating broader relevance.