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Recognition of Non-standard Base Pairs by Triplex-Forming Oligonucleotides Containing an Expanded Genetic Alphabet | Synapse
March 3, 2026
Open Access
Recognition of Non-standard Base Pairs by Triplex-Forming Oligonucleotides Containing an Expanded Genetic Alphabet
DR
David A. Rusling
Institute of Biomedical Science
MB
Michael Brazzill
Institute of Biomedical Science
RM
Ruolin Ma
University of Portsmouth
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Puntos clave
Identification of non-standard base pairs enhances understanding of molecular recognition.
Expanded genetic alphabet allows for more versatile interactions within DNA structures.
Analysis using triplex-forming oligonucleotides reveals significant differences in binding affinities.
These findings highlight potential applications in gene regulation and synthetic biology.
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Cite This Study
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Rusling et al. (Tue,) studied this question.
synapsesocial.com/papers/69a761fcc6e9836116a30131
https://doi.org/https://doi.org/10.21203/rs.3.rs-8652009/v1