Comparison of Sentinel Lymph Node Mapping with Comprehensive Lymphadenectomy in p53-mutated Endometrial Cancer: A prospective, multicenter, non-inferiority, open-label, de-escalation, randomized, controlled trial (Study Protocol - SENTIMETREP53)

Puntos clave

• Sentinel lymph node mapping shows feasible outcomes comparable to comprehensive lymphadenectomy in endometrial cancer cases.
• The trial is set to enroll 300 participants to evaluate efficacy and safety through various metrics.
• Randomized controlled trial protocol focuses on a de-escalation approach to surgical interventions in specific cancer mutations.
• Findings could potentially lead to less invasive options, improving patient quality of life while maintaining treatment effectiveness.