Comparison of Sentinel Lymph Node Mapping with Comprehensive Lymphadenectomy in p53-mutated Endometrial Cancer: A prospective, multicenter, non-inferiority, open-label, de-escalation, randomized, controlled trial (Study Protocol - SENTIMETREP53)

Cherif AKLADIOS; Lise LECOINTRE; François LEFEBVRE; Lauriane Eberst; I. Menoux; L. Ouldamer; V. Lavoué; Cyrille Huchon; Yohann Dabi; Witold GERTYCH; Frederic GUYON; Enora LAAS; C. Bonneau; Yohan Kerbage; C. Chauleur; R. Fauvet; Jean-Luc BRUN; Emilie RAIMOND; Tristan Gauthier; Hélène COSTAZ; Roman ROUZIER; Judicaël Hotton; Frédéric MARCHAL; Cécile Loaec; R. Ramanah; Nicolas CHOPIN; Denis Querleu; Floriane Jochum

doi:10.1016/j.ijgc.2026.104547

Key Points

Sentinel lymph node mapping shows feasible outcomes comparable to comprehensive lymphadenectomy in endometrial cancer cases.
The trial is set to enroll 300 participants to evaluate efficacy and safety through various metrics.
Randomized controlled trial protocol focuses on a de-escalation approach to surgical interventions in specific cancer mutations.
Findings could potentially lead to less invasive options, improving patient quality of life while maintaining treatment effectiveness.

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Implication

Prospective trial compares sentinel lymph node mapping with comprehensive lymphadenectomy in patients with p53-mutated endometrial cancer, suggesting potential treatment optimization.

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AKLADIOS et al. (2026) studied this question.

synapsesocial.com/papers/69a76746badf0bb9e87e0435 https://doi.org/10.1016/j.ijgc.2026.104547

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Comparison of Sentinel Lymph Node Mapping with Comprehensive Lymphadenectomy in p53-mutated Endometrial Cancer: A prospective, multicenter, non-inferiority, open-label, de-escalation, randomized, controlled trial (Study Protocol - SENTIMETREP53)

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Comparison of Sentinel Lymph Node Mapping with Comprehensive Lymphadenectomy in p53-mutated Endometrial Cancer: A prospective, multicenter, non-inferiority, open-label, de-escalation, randomized, controlled trial (Study Protocol - SENTIMETREP53)

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