7-Ketocholesterol promotes T cell migration through Ca2+-NFATc1 pathway-mediated F-actin polymerization and proinflammatory cytokine production in oral lichen planus | Synapse
March 3, 2026Open Access
7-Ketocholesterol promotes T cell migration through Ca2+-NFATc1 pathway-mediated F-actin polymerization and proinflammatory cytokine production in oral lichen planus
Puntos clave
T cell migration is significantly enhanced by 7-ketocholesterol, indicating its role in immune response.
The study highlights increased expression of proinflammatory cytokines IL1B, CCL4, and IL6 due to this pathway activation.
Observational analysis indicates that migration is mediated through the Ca2+-NFATc1 pathway and F-actin polymerization.
These findings underscore the potential importance of 7-ketocholesterol in the inflammatory processes of oral lichen planus.
Resumen
7KC could promote T cell migration through Ca2+ -NFATc1 pathway-mediated F-actin polymerization and expression of IL1B/CCL4/IL6 in OLP.