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March 3, 2026Frontiers in Immunology0 citationsOpen Access

7-Ketocholesterol promotes T cell migration through Ca2+-NFATc1 pathway-mediated F-actin polymerization and proinflammatory cytokine production in oral lichen planus

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QJQin JiangYTYu-Xi TangGZGang Zhou

Key Points

  • T cell migration is significantly enhanced by 7-ketocholesterol, indicating its role in immune response.
  • The study highlights increased expression of proinflammatory cytokines IL1B, CCL4, and IL6 due to this pathway activation.
  • Observational analysis indicates that migration is mediated through the Ca2+-NFATc1 pathway and F-actin polymerization.
  • These findings underscore the potential importance of 7-ketocholesterol in the inflammatory processes of oral lichen planus.

Abstract

7KC could promote T cell migration through Ca2+ -NFATc1 pathway-mediated F-actin polymerization and expression of IL1B/CCL4/IL6 in OLP.

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Cite This Study

Jiang et al. (2026) studied this question.

synapsesocial.com/papers/69a767bfbadf0bb9e87e22abhttps://doi.org/10.3389/fimmu.2026.1682589
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