Mechanistic insight into the anti-inflammatory and lung-protective effects of Agrimonia pilosa extract via NF-κB/MAPK inhibition in ovalbumin- and lipopolysaccharide-induced respiratory inflammation models.

Puntos clave

• The research aims to explore how Agrimonia pilosa extract affects inflammation in lung diseases.
• Used ovalbumin- and lipopolysaccharide-induced models to simulate respiratory inflammation.
• Measured NF-κB and MAPK signaling pathways as indicators of inflammation.
• Analyzed the effects on proteolysis and apoptosis in lung tissues.
• Agrimonia pilosa extract significantly inhibited NF-κB and MAPK signaling.
• It decreased markers of inflammation and improved lung function in models.
• Regulation of proteolysis and apoptosis was observed, supporting lung protection.