Mechanistic insight into the anti-inflammatory and lung-protective effects of Agrimonia pilosa extract via NF-κB/MAPK inhibition in ovalbumin- and lipopolysaccharide-induced respiratory inflammation models.

Yeong-Geun Lee; Jeong Eun Kwon; Dae Won Park; Hae Rim Lee; Jinhyuk Lee; Yong-Min Choi; Eun-Ji Cho; Se Chan Kang

doi:10.1080/13880209.2026.2627661

December 1, 2026

Mechanistic insight into the anti-inflammatory and lung-protective effects of Agrimonia pilosa extract via NF-κB/MAPK inhibition in ovalbumin- and lipopolysaccharide-induced respiratory inflammation models.

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Key Points

The research aims to explore how Agrimonia pilosa extract affects inflammation in lung diseases.
Used ovalbumin- and lipopolysaccharide-induced models to simulate respiratory inflammation.
Measured NF-κB and MAPK signaling pathways as indicators of inflammation.
Analyzed the effects on proteolysis and apoptosis in lung tissues.
Agrimonia pilosa extract significantly inhibited NF-κB and MAPK signaling.
It decreased markers of inflammation and improved lung function in models.
Regulation of proteolysis and apoptosis was observed, supporting lung protection.

Implication

Uncovers the anti-inflammatory effects of Agrimonia pilosa extract in respiratory inflammation, suggesting a safe treatment option.

Abstract

AP exhibits anti-inflammatory and lung-protective effects by inhibiting NF-κB/MAPK signaling and regulating proteolysis and apoptosis, indicating it as a safe, effective treatment for airway inflammation.

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Cite This Study

Lee et al. (2026) studied this question.

synapsesocial.com/papers/69a7cd8cd48f933b5eeda0b3 https://doi.org/10.1080/13880209.2026.2627661

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Mechanistic insight into the anti-inflammatory and lung-protective effects of Agrimonia pilosa extract via NF-κB/MAPK inhibition in ovalbumin- and lipopolysaccharide-induced respiratory inflammation models.

Key Points

Implication

Abstract

Discussion

Cite This Study

Mechanistic insight into the anti-inflammatory and lung-protective effects of Agrimonia pilosa extract via NF-κB/MAPK inhibition in ovalbumin- and lipopolysaccharide-induced respiratory inflammation models.

Key Points

Implication

Abstract

Discussion

Cite This Study

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