What question did this study set out to answer?

The research aims to identify shared genes across ageing and neurodegenerative diseases such as Alzheimer's and Parkinson's.

March 12, 2026Open Access

A Meta-analysis to Identify Common Key Genes Across Ageing, Alzheimer's and Parkinson's Diseases.

Puntos clave

The research aims to identify shared genes across ageing and neurodegenerative diseases such as Alzheimer's and Parkinson's.
Conducted a meta-analysis integrating transcriptomic data, network analysis, and miRNA studies.
Focused on identifying common molecular pathways among the diseases.
Analyzed physiological ageing alongside pathological neurodegeneration.
Identified a neurodegenerative molecular core shared across the three conditions.
Revealed several key regulatory nodes that could serve as targets for new therapies.
Demonstrated systems-level convergence in gene expression related to ageing and disease.

Resumen

This study defines a shared neurodegenerative molecular core that bridges physiological AG with pathological neurodegeneration. The integration of transcriptomic, network, and miRNA analyses reveals systems-level convergence and identifies key regulatory nodes as attractive targets for cross-disease therapeutic strategies.

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Cite This Study

Chaurasiya et al. (Fri,) studied this question.

synapsesocial.com/papers/69b2573196eeacc4fcec5d8b https://doi.org/https://doi.org/10.1177/09727531261420619

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