What question did this study set out to answer?

To assess the risk of eosinophilic granulomatosis with polyangiitis associated with leukotriene receptor antagonists and explore underlying genes and mechanisms.

March 12, 2026Open Access

Leukotriene receptor antagonists and eosinophilic granulomatosis with polyangiitis: a disproportionality analysis from FAERS, JADER, CVAR databases integrated with network pharmacology

Puntos clave

To assess the risk of eosinophilic granulomatosis with polyangiitis associated with leukotriene receptor antagonists and explore underlying genes and mechanisms.
Conducted disproportionality analysis using FAERS, JADER, and CVAR databases.
Utilized network pharmacology to identify potential genes and mechanisms related to LTRA-induced EGPA.
Indicated that LTRAs may significantly increase the risk of developing EGPA.
Identified several potential genes involved in the mechanisms of LTRA-induced EGPA.

Resumen

Our study revealed LTRAs could increase the risk of EGPA, and initially explored potential genes and mechanisms of LTRAs-induced EGPA. It is helpful for clinicians to be alerted to the risk of EGPA during LTRAs administration.

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