Leukotriene receptor antagonists and eosinophilic granulomatosis with polyangiitis: a disproportionality analysis from FAERS, JADER, CVAR databases integrated with network pharmacology

Key Points

• To assess the risk of eosinophilic granulomatosis with polyangiitis associated with leukotriene receptor antagonists and explore underlying genes and mechanisms.
• Conducted disproportionality analysis using FAERS, JADER, and CVAR databases.
• Utilized network pharmacology to identify potential genes and mechanisms related to LTRA-induced EGPA.
• Indicated that LTRAs may significantly increase the risk of developing EGPA.
• Identified several potential genes involved in the mechanisms of LTRA-induced EGPA.