What question did this study set out to answer?

The study aims to compare glucose concentrations in plasma versus serum samples for diabetes screening.

March 13, 2026Open Access

Comparison of glucose concentrations in simultaneously collected plasma and serum samples from outpatients in a routine laboratory setting

RMRobert MüllerRavensburg University of Cooperative Education DMDiethard MüllerRavensburg University of Cooperative Education DPDietmar PlonnéRavensburg University of Cooperative Education

Puntos clave

The study aims to compare glucose concentrations in plasma versus serum samples for diabetes screening.
Simultaneous collection of plasma and serum samples from outpatients.
Glucose measurements conducted in a routine laboratory setting.
Assessment of glycolysis inhibition in both sample types.
Serum glucose concentrations are similar to those of NaF plasma.
Neither serum nor NaF plasma completely inhibits glycolysis, questioning their diagnostic reliability.

Resumen

In real-world outpatient settings, glucose measurement in on-site centrifuged serum with separator gel does not appear to present a clinically relevant disadvantage for diabetes mellitus screening compared to on-site uncentrifuged NaF plasma. However, neither serum nor non-acidified NaF plasma ensures complete inhibition of in vitro glycolysis and must therefore be regarded as suboptimal for definitive diagnostic purposes.

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Cite This Study

Müller et al. (Tue,) studied this question.

synapsesocial.com/papers/69b3ab4c02a1e69014ccc01b https://doi.org/https://doi.org/10.1371/journal.pone.0344562

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