What question did this study set out to answer?

This research aims to compare the effects of whole-blood transfusion versus component therapy in adult trauma patients.

March 13, 2026

Whole-Blood vs Component Therapy in Adult Trauma: An Updated Systematic Review and Meta-Analysis.

Puntos clave

This research aims to compare the effects of whole-blood transfusion versus component therapy in adult trauma patients.
Conducted a systematic review and meta-analysis of existing studies
Analyzed mortality rates following whole-blood and component therapy
Included both civilian and military adult trauma patients
Whole-blood transfusion associated with reduced mortality in civilian trauma patients
No significant mortality reduction observed in military trauma patients
Wide 95% prediction intervals indicate substantial variability in outcomes across different settings

Resumen

In this updated systematic review and meta-analysis, whole-blood transfusion was associated with reduced mortality in civilian but not military adult trauma patients, although the wide 95% PIs suggest substantial heterogeneity, indicating that benefits may vary considerably across settings. These findings support selective whole-blood transfusion protocol implementation in civilian centers while highlighting the need for refined patient selection criteria.

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Cite This Study

Ibrahim et al. (Wed,) studied this question.

synapsesocial.com/papers/69b3ad1302a1e69014ccf649 https://doi.org/https://doi.org/10.1001/jamasurg.2026.0197

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