Systematic review shows whole-blood transfusion reduces mortality in civilian trauma, suggesting targeted protocols.
In this updated systematic review and meta-analysis, whole-blood transfusion was associated with reduced mortality in civilian but not military adult trauma patients, although the wide 95% PIs suggest substantial heterogeneity, indicating that benefits may vary considerably across settings. These findings support selective whole-blood transfusion protocol implementation in civilian centers while highlighting the need for refined patient selection criteria.
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Ibrahim et al. (2026) studied this question.
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