Evaluation of HIV-1 transmitted drug-resistance among subtypes circulating from 2022 to 2024 in Italy: a refined analysis through next-generation sequencing

Puntos clave

• This evaluation aims to assess the prevalence of HIV-1 transmitted drug-resistance (TDR) among circulating subtypes in Italy.
• Utilized next-generation sequencing (NGS) for refined analysis.
• Analyzed TDR prevalence rates at varying Sanger-like thresholds.
• Focused on HIV-1 non-B subtypes circulating in the region.
• TDR prevalence was approximately 12% at Sanger-like threshold.
• Prevalence increased to around 15% when NGS was set at 10%.
• Detected TDR has a negligible impact on susceptibility to current antiretrovirals.