Non-Catalytic Low-Cost and Sustainable Amidation using a Twisted Amide

Puntos clave

• The aim is to develop a cost-effective and environmentally friendly method for amidation using twisted amides.
• Converted carboxylic acid to twisted amide
• Used inexpensive tosyl isocyanate and bromoacetate
• Evaluated synthesis efficiency and environmental impact
• Achieved synthesis of twisted amide with reduced costs
• Demonstrated environmentally friendly reaction conditions
• Illustrated potential for broader applications in sustainable chemistry