Non-Catalytic Low-Cost and Sustainable Amidation using a Twisted Amide

Takefumi Kuranaga; Ai Koyama; Kosuke Shimizu; Tensei Tokuda; Hideaki Kakeya

doi:10.1039/d6ob00340k

January 1, 2025Organic & Biomolecular Chemistry

Non-Catalytic Low-Cost and Sustainable Amidation using a Twisted Amide

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Key Points

The aim is to develop a cost-effective and environmentally friendly method for amidation using twisted amides.
Converted carboxylic acid to twisted amide
Used inexpensive tosyl isocyanate and bromoacetate
Evaluated synthesis efficiency and environmental impact
Achieved synthesis of twisted amide with reduced costs
Demonstrated environmentally friendly reaction conditions
Illustrated potential for broader applications in sustainable chemistry

Implication

Demonstrates low-cost amidation of carboxylic acid using twisted amide, suggesting an eco-friendly synthesis approach.

Abstract

Cost reductions and environmental friendliness have been strongly desired in amide synthesis. In this study, carboxylic acid was converted to a twisted amide using inexpensive tosyl isocyanate and bromoacetate. The...

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Cite This Study

Kuranaga et al. (2025) studied this question.

synapsesocial.com/papers/69c37b62b34aaaeb1a67db72 https://doi.org/10.1039/d6ob00340k

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Non-Catalytic Low-Cost and Sustainable Amidation using a Twisted Amide

Key Points

Implication

Abstract

Discussion

Cite This Study

Non-Catalytic Low-Cost and Sustainable Amidation using a Twisted Amide

Key Points

Implication

Abstract

Discussion

Cite This Study

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